Phytochemical profiling and in silico target exploration of hexadecanoic acid from Bergenia ciliata: An integrative approach combining docking, absorption, distribution, metabolism, and excretion, and biological activity studies
Natural products are essential to the development and discovery of new medications because of their abundant supply of bioactive chemicals, which fuel important advancements in medicine. Bergenia ciliata is one of the many ethnomedicinal plants found in the Western Himalayas, which are renowned for its varied medicinal flora. In this investigation, B. ciliata was extracted using methanol after being gathered from the high-altitude areas of Srinagar and Khirsu (Garhwal), Uttarakhand. Numerous phytochemical components were identified in the extract when analyzed using gas chromatography-mass spectrometry. When the agar well diffusion method was used to evaluate antibacterial efficacy, the methanolic extract showed significant inhibitory action, especially against Staphylococcus aureus (20.65 ± 0.49 mm). Notable antibacterial qualities of the extract were demonstrated by all eight tested bacterial strains. In addition, neutral red uptake cytotoxicity assays and 2,2-diphenyl-1-picrylhydrazyl radical scavenging were used to assess the extract’s biological potential. The extract’s IC50 value of 317.9 ± 0.12 μg/mL showed encouraging antioxidant activity. Molecular docking of hexadecanoic acid with six protein targets exhibited varying degrees of affinity and interaction potential across different bacterial proteins. The highest binding affinity observed for Hexadec+4KRA, i.e., −6.4 kcal/mol, suggests its potential as a target for further studies.
Vishwakarma S, Chaudhry V, Chand S, Prakash S, Singh K, Singh A, Prasad R, Chandra H. Phytochemical profiling and in silico target exploration of hexadecanoic acid from Bergenia ciliata: An integrative approach combining docking, absorption, distribution, metabolism, and excretion, and biological activity studies. J Appl Biol Biotech 2025. Article in Press. http://doi.org/10.7324/JABB.2025.253184
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Nandhini Govindaraj, Silambu Selvi Kumbamoorthy, Vishnupriya Subramaniyan, Sundaresan SivapathamEffects of triclosan at different salinity levels on swimming behavior, reproduction, and antioxidant status in the marine rotifer Brachionus plicatilis
Ojeshvi Ethiraj, Arjun Surya Subramanya, Abdul Raziq Raheem, Jaganathan Murugesan KuppuswamyBiostimulant effect of hydrolyzed Spirulina (Ficocyan®) on bioactive compounds in pigmented corn from Jalisco, Mexico
Raúl Armando Chavarín González, Valeria Yadira Ortiz Sosa, Ramón Rodríguez Macias, Ricardo Solis Zamora, Luis Alberto Anguiano Sevilla, Juan Carlos Pizano Andrade, Mario Alberto Ruiz LópezMicroalgae: A valuable bio-resource for pharmaceuticals and nutraceuticals
Sanjesh Tiwari, Vandana Sharma, Anuradha Patel, Vaishali Yadav, Charu Kalra, Garima Singh, Namira Arif, Arushi Khandelwal, Anupam Tiwari, Dileep Kumar SinghEco-friendly fabrication of silver nanoparticles from the red macroalga Scinaia moniliformis and evaluation of their biomedical activities
Hemangiben Sheth, Charumati JhaPhytochemical and ethnobotanical investigation of 29 aromatic and medicinal plants from Dakhla-Oued Ed-Dahab region and their traditional uses
Hajar Sadki, Oukacha Amri, Rachid Ait Taher, Khadija El Mehrach, Fadma Fahmi, Hakima Lounis, Ouafae Benkhnigue, Brahim Alayoua, Saida TahrouchPrebiotic properties of polysaccharide extracts from Cordyceps militaris mycelium: Potentials for functional food and drink applications
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