Genetically modified crops: Advances, biosafety, and the quest for sustainable food

Satyajit Saurabh   

Open Access   

Published:  Oct 28, 2025

DOI: 10.7324/JABB.2026.244399
Abstract

Since antiquity, humans have been highly influenced by genetic makeup for crop selection and its domestication through selective breeding and mutation breeding. Novel crosses for modifying the genetic makeup to produce hybrids with the beneficial trait(s) are started by traditional crop breeders. Further, the alterations in genetic makeup are introduced by mutations and plant tissue culture. Now, the modern biotechnological strategies enable gene(s) transfer between species, for genomic manipulation, which could not occur naturally. Genetic manipulation results in producing genetically modified (GM) crops with beneficial traits, including quality improvement, increased yield, and stress tolerance. As GM crops should be safe for consumption and the environment, GM produce, as a whole crop, crop part, or processed food, has to be considered for an early safety evaluation. Because the biotechnology involved in genetic manipulation may bring some known and unknown risks. As per our knowledge at present, there are three categories of potential risks related to the use of modern biotechnology: (i) risks related to the health of humans, animals, and plants, (ii) risks related to the protection of biodiversity and agricultural sustainability, and (iii) risks related to the ethical and socioeconomic issues. With all-new strategies and technologies, several doubts, questions, and concerns are being raised about tampering with Mother Nature and the associated risks to the environment and consumer health. This review aims to address several key issues associated with recombinant technology and GM foods, such as biosafety, ecological and environmental concerns, and health risks.


Keyword:     Crop improvement Biotechnology Biosafety Biosecurity Environment Regulations


Citation:

Saurabh S. Genetically modified crops: Advances, biosafety, and the quest for sustainable food. J Appl Biol Biotech 2025. Article in Press. http://doi.org/10.7324/JABB.2026.244399

Copyright: Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

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Ajar Nath Yadav, Divjot Kour, Ahmed M. Abdel-Azeem, Murat Dikilitas, Abd El-Latif Hesham, Amrik Singh Ahluwalia

Nanotechnology for the bioremediation of heavy metals and metalloids

Urja Sharma, Jai Gopal Sharma

Emerging microplastic contamination in ecosystem: An urge for environmental sustainability

Akanksha Saini, Jai Gopal Sharma

Bioremediation and Waste Management for Environmental Sustainability

Ajar Nath Yadav, Deep Chandra Suyal, Divjot Kour, Vishnu D. Rajput, Ali Asghar Rastegari, Joginder Singh

Microbes mediated plastic degradation: A sustainable approach for environmental sustainability

Harpreet Kour, Sofia Shareif Khan, Divjot Kour, Shafaq Rasool, Yash Pal Sharma, Pankaj Kumar Rai, Sangram Singh, Kundan Kumar Chaubey, Ashutosh Kumar Rai, Ajar Nath Yadav

Microbe-mediated remediation of dyes: Current status and future challenges

Kriti Akansha, Tanvir Kaur, Ashok Yadav, Divjot Kour, Ashutosh Kumar Rai, Sangram Singh, Shashank Mishra, Lalit Kumar, Kanika Miglani, Karan Singh, Ajar Nath Yadav

Environment and climate change: Influence on biodiversity, present scenario, and future prospect

Divjot Kour, Kanwaljit Kaur Ahluwalia, Seema Ramniwas, Sanjeev Kumar, Sarvesh Rustagi, Sangram Singh, Ashutosh Kumar Rai, Ajar Nath Yadav,, Amrik Singh Ahluwalia

Global research contributions on orchids: A scientometric review of 20 years

Payel Goswami, Sucheta Bhattacharjee, Sudip Bhattacharjee

Using RAPD and ISSR markers to assess genetic diversity and conservation of Bruguiera gymnorrhiza (L.) Lam. for sustainable management on Kerala's West Coast

Sreeram Sudhir, Sankara Velmani Vel, Hariharan Selvam, Arumugam Arunprasath

Sensitive and cost-effective citrate-based RNA extraction procedure for isolation of RNA from Tilapia Lake Virus-infected fish

S.R. Saranya, R. Sudhakaran

Microplastics in the ecosystems: Impacts on environmental sustainability

Komal Kumari, Ravinder Singh, Madhuben Sharma, Renuka Jyothi S., Anirudh Gupta, Neelam Yadav, Narinderpal Kaur, Sangram Singh, Sheikh Shreaz, Rajeshwari Negi, Ajar Nath Yadav,