Evaluation of acute and sub-acute toxicity assessment of marine diatom Thalassiosira weissflogii

Ashashalini Albert; Syed Ali Mohamed Yacoob; Anuradha Venketraman; Ravikumar Sundaram; Habeeb Shaik Mohideen

doi:10.7324/JABB.2021.95.1s3

Abstract References Article Metrics Similar Articles Request Permission Related Search Citation Alert By Google Scholar Comment On This Article

Abstract

With positive effects on human health, several bioactive compounds from marine microalgae have been demonstrated for their diverse biological activities. As new technologies are emerging for the study of bioactive compounds from natural sources, determination of their toxicity profile becomes inevitable. Since diatoms are rich in minerals and produce secondary metabolites, diatoms were reported as potent anti-cancer agents. It has been proved that diatoms can be used as potentially effective carrier in treating cancer diseases especially in targeted drug delivery treatments. Various in vivo studies have shown that there are no significant symptoms of tissue damage in animal models, thus suggesting the aptness of a diatoms extract of Thalassiosira weissflogii in cancer treatments. The diatoms methanolic extract showed hopeful paths for further preclinical studies in discovering their pharmacological potential. In future, these marine diatoms which are rich in cytotoxic compounds against cancer cells will be connected for the discovery of new lead compounds. The diatoms of T. weissflogii could be further assessed for their efficiency against cancer models to attain targeted delivery and harmless treatment.

Keyword: Acute toxicity biocompatibility Thalassiosira weissflogii sub acute toxicity histopathological examination

Citation:

Ashashalini A, Yacoob SAM, Anuradha V, Sundaram R, Mohideen HS. Evaluation of acute and sub-acute toxicity assessment of marine diatom Thalassiosira weissflogii. J Appl Biol Biotech, 2021;9(S1):13–19.

Copyright: Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike license.

HTML Full Text

Reference

1.Sasidharan S, Darah I, Jain K. Antimicrobial activity of crude extract from G. changii. Proceeding of the 14th National Biotechnology Seminar, Penag, Malaysia, Ministry of Science, Technology & Innovation and Utilization and Universiti Sains Malaysis, Malaysia, 2000, pp 17-9.
2. Purchase IF, Botham PA, Bruner LH, Flibt OP, Frazier JM, Stokes WS. Workshop overview: scientific and regulatory challenges for the reduction, refinement and replacement of animals in toxicity testing. J Toxicol Sci 1998;43(2):86-101.
3. Adebayo JO, Yakubu MT, Egwim EC, Owoyele VB, Enaibe BU. Effect of ethanolic extract of Khaya senegalensis on some biochemical parameters of rat kidney. J Ethnopharm 2003;88(1):69-72. https://doi.org/10.1016/S0378-8741(03)00193-4
4. Reichelt JL, Borowitzka MA. Antimicrobial activity from marine algae: results of a large-scale screening programme. In: Eleventh International Seaweed Symposium. Springer, Dordrecht, 1984, pp 158-68.
5. Pesando D. Antibacterial and antifungal activities of marine algae. In Akatsuka I (ed.), Introduction to Applied Phycology. SPB Academic Publishing, The Hague, pp 3-26.
6. Belay A. The potential application of Spirulina (Arthrospira) as a nutritional and therapeutic supplement in health management. J Funct Food 2002; 5(2): 27-48.
7. Karpov L, Brown II, Poltavtseva NV, Ersova ON, Karakis SG, Vasileve TV. The postradiation use of vitamin-containing complexes and a phycocyanin extract in a radiation lesion in rats. Radiatsionnaia biologiia, radioecologiia/Rossiiskaia akademiia nauk. J Algal Biomass Utiliz 1999;40(3):310-4.
8. Moreau J, Pesando D, Bernard P, Caram B, Pionnat JC. Seasonal variations in the production of antifungal substances by some dictyotales (brown algae) from the French Mediterranean coast. J Hydrobiol 1998;162(2):157-62. https://doi.org/10.1007/BF00014538
9. Shalini AA, Syed Ali M, Anuradha V, Yogananth N. GCMS analysis and in vitro antibacterial and anti-inflammatory study on methanolic extract of Thalassiosira weissflogii. Biocatal Agric Biotech 2019;19:1- 7.
10. Guillard RRL, Ryther JH. Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt and Detonula confervacea Cleve. Cancer J Microb 1962;8:229-39. https://doi.org/10.1139/m62-029
11. Benditha DB, Milton RDR, Arwen SCR, Maricris AD, Grace MMM, Andrea RM, et al. In vitro activity of ethanolic extract of Lentinus strigosus mycelia in N2 wild strain Caenorhabditis elegans- an animal model for obesity and its chemical composition. J Appl Biol Biotech 2021;9(1):41-6.
12. Adhoni SA, Shivasharan CT, Kaliwal BB. Physicochemical studies of freshwater lakes in Dharwad and screening of algal species for biofuel production. Europ Exp Biol 2015;5(4):60-7.
13. Burtis CA, Ashwood ER. Tietz Textbook of Clinical Chemistry. 3rd edition, Philadelphia W.B. Saunders Company, Philadelphia, PA, pp 336-56, 1999.
14. Jothy SL, Zakaria Z, Chen Y, Lau YL, Latha LY, Sasidharan S. Acute oral toxicity of methanolic seed extract of Cassia fistula in mice. Molecules 2001;16:5268-82. https://doi.org/10.3390/molecules16065268
15. Raphael CE, Obioma UN. Acute and sub-acute oral toxicity study on the flavonoid rich fraction of Monodora tenuifolia seed in albino rats. Asian Pac J Trop Biomed 2014;4:194-202. https://doi.org/10.1016/S2221-1691(14)60231-8
16. Bogne KP, Penla, BV, Lontsi D, Etoa FX. Antibacterial activities of the extracts and conessine from Holarrhena floribunda G. Don. (Apocynaceae). Afric Trad Compl Altern Med 2007;4(3):352-6.
17. Ifedi EN, Ajayi IA, Anibuko SA. Assessment of acute and sub-chronic toxicological effects of Neocarya Macrophylla seed cake on wistar rats. Annals Food Sci Tech 2017;18(4):700-12.
18. Kafaie S, Loh SP, Mohtarrudin N. Acute and sub-chronic toxicological assessment of Nannochloropsis oculata in rats. Afr J Agri Res 2012;7:1220-5. https://doi.org/10.5897/AJAR11.1793
19. Shuid A, Bakar MFA, Ariff T, Muhammad N. The anti-osteoporotic effect of Eurycoma Longifolia in aged orchidectomised rat model. The Aging Male 2011;14(3):150-4. https://doi.org/10.3109/13685538.2010.511327
20. Prakash S, Sasikala SL, Huxley VAJ. In vivo acute and sub-acute toxicity study of antimycobacterial compounds from marine micro algal extracts in albino mice as animal model. Asian J Ani Sci 2009;4(1):91-7.
21. Hosseinzadeha H, Shakibb SS, Samenic AK, Taghiabadi E. Acute and subacute toxicity of safranal, a constituent of saffron, in mice and rats. Iranian J Pharma Res 2013;12(1):93-9.

Article Metrics

128 Views 93 Downloads 221 Total

Year

Month

Related Search

By author names

Albert A [PubMed] [Google Scholar ]

Yacoob S A M [PubMed] [Google Scholar ]

Venketraman A [PubMed] [Google Scholar ]

Sundaram R [PubMed] [Google Scholar ]

Mohideen H S [PubMed] [Google Scholar ]

By article title

1.Sasidharan S, Darah I, Jain K. Antimicrobial activity of crude extract from G. changii. Proceeding of the 14th National Biotechnology Seminar, Penag, Malaysia, Ministry of Science, Technology & Innovation and Utilization and Universiti Sains Malaysis, Malaysia, 2000, pp 17-9.

2. Purchase IF, Botham PA, Bruner LH, Flibt OP, Frazier JM, Stokes WS. Workshop overview: scientific and regulatory challenges for the reduction, refinement and replacement of animals in toxicity testing. J Toxicol Sci 1998;43(2):86-101.

3. Adebayo JO, Yakubu MT, Egwim EC, Owoyele VB, Enaibe BU. Effect of ethanolic extract of Khaya senegalensis on some biochemical parameters of rat kidney. J Ethnopharm 2003;88(1):69-72. https://doi.org/10.1016/S0378-8741(03)00193-4

4. Reichelt JL, Borowitzka MA. Antimicrobial activity from marine algae: results of a large-scale screening programme. In: Eleventh International Seaweed Symposium. Springer, Dordrecht, 1984, pp 158-68.

5. Pesando D. Antibacterial and antifungal activities of marine algae. In Akatsuka I (ed.), Introduction to Applied Phycology. SPB Academic Publishing, The Hague, pp 3-26.

6. Belay A. The potential application of Spirulina (Arthrospira) as a nutritional and therapeutic supplement in health management. J Funct Food 2002; 5(2): 27-48.

7. Karpov L, Brown II, Poltavtseva NV, Ersova ON, Karakis SG, Vasileve TV. The postradiation use of vitamin-containing complexes and a phycocyanin extract in a radiation lesion in rats. Radiatsionnaia biologiia, radioecologiia/Rossiiskaia akademiia nauk. J Algal Biomass Utiliz 1999;40(3):310-4.

8. Moreau J, Pesando D, Bernard P, Caram B, Pionnat JC. Seasonal variations in the production of antifungal substances by some dictyotales (brown algae) from the French Mediterranean coast. J Hydrobiol 1998;162(2):157-62. https://doi.org/10.1007/BF00014538

9. Shalini AA, Syed Ali M, Anuradha V, Yogananth N. GCMS analysis and in vitro antibacterial and anti-inflammatory study on methanolic extract of Thalassiosira weissflogii. Biocatal Agric Biotech 2019;19:1- 7.

10. Guillard RRL, Ryther JH. Studies of marine planktonic diatoms. I. Cyclotella nana Hustedt and Detonula confervacea Cleve. Cancer J Microb 1962;8:229-39. https://doi.org/10.1139/m62-029

11. Benditha DB, Milton RDR, Arwen SCR, Maricris AD, Grace MMM, Andrea RM, et al. In vitro activity of ethanolic extract of Lentinus strigosus mycelia in N2 wild strain Caenorhabditis elegans- an animal model for obesity and its chemical composition. J Appl Biol Biotech 2021;9(1):41-6.

12. Adhoni SA, Shivasharan CT, Kaliwal BB. Physicochemical studies of freshwater lakes in Dharwad and screening of algal species for biofuel production. Europ Exp Biol 2015;5(4):60-7.

13. Burtis CA, Ashwood ER. Tietz Textbook of Clinical Chemistry. 3rd edition, Philadelphia W.B. Saunders Company, Philadelphia, PA, pp 336-56, 1999.

14. Jothy SL, Zakaria Z, Chen Y, Lau YL, Latha LY, Sasidharan S. Acute oral toxicity of methanolic seed extract of Cassia fistula in mice. Molecules 2001;16:5268-82. https://doi.org/10.3390/molecules16065268

15. Raphael CE, Obioma UN. Acute and sub-acute oral toxicity study on the flavonoid rich fraction of Monodora tenuifolia seed in albino rats. Asian Pac J Trop Biomed 2014;4:194-202. https://doi.org/10.1016/S2221-1691(14)60231-8

16. Bogne KP, Penla, BV, Lontsi D, Etoa FX. Antibacterial activities of the extracts and conessine from Holarrhena floribunda G. Don. (Apocynaceae). Afric Trad Compl Altern Med 2007;4(3):352-6.

17. Ifedi EN, Ajayi IA, Anibuko SA. Assessment of acute and sub-chronic toxicological effects of Neocarya Macrophylla seed cake on wistar rats. Annals Food Sci Tech 2017;18(4):700-12.

18. Kafaie S, Loh SP, Mohtarrudin N. Acute and sub-chronic toxicological assessment of Nannochloropsis oculata in rats. Afr J Agri Res 2012;7:1220-5. https://doi.org/10.5897/AJAR11.1793

19. Shuid A, Bakar MFA, Ariff T, Muhammad N. The anti-osteoporotic effect of Eurycoma Longifolia in aged orchidectomised rat model. The Aging Male 2011;14(3):150-4. https://doi.org/10.3109/13685538.2010.511327

20. Prakash S, Sasikala SL, Huxley VAJ. In vivo acute and sub-acute toxicity study of antimycobacterial compounds from marine micro algal extracts in albino mice as animal model. Asian J Ani Sci 2009;4(1):91-7.

21. Hosseinzadeha H, Shakibb SS, Samenic AK, Taghiabadi E. Acute and subacute toxicity of safranal, a constituent of saffron, in mice and rats. Iranian J Pharma Res 2013;12(1):93-9.